题目/Title：Design of a Compact Wireless EEG Recorder With Extra-High Sampling Rate and Precise Time Synchronization for Auditory Brainstem Response
作者/Author：
Jiaxin Lei, Xin Li, Wenjing Chen, Anhe Wang, Qingquan Han, Shuo Bai, Milin Zhang
期刊/Journal：IEEE Sensors Journal
年份/Issue Date：2022Mar.
卷（期）及页码/Volume（No.）&pages：Vol.22, No.5, pp.4484-4493
摘要/Abstract：
This paper proposed a compact wearable Electroencephalography (EEG) acquisition and analysis system targeting for event-related, wide-bandwidth biopotentials including Auditory Brainstem Response (ABR). The proposed system enables a 2-channel high EEG sampling mode with a sampling rate up to 16kHz, and an 8-channel low EEG sampling mode with a sampling rate of 4kHz. An audio codec is integrated generating synchronized audio stimulation and potential audio recording. A Bluetooth 5 based in-the-air protocol is designed featuring lossless neural data compression algorithm and lost-packet-retransmission strategy. Hydrogels are used as the tissue interface on the electrodes to improve the conductivity and stability. A precise time synchronization method with a standard deviation of 0.07μs is implemented for timestamping when external stimulus is requested. A Graphic User Interface (GUI) is developed for remote control of the proposed device as well as for real-time display of the acquired neural signal and analysis results. Both bench test and in-vivo click-ABRs test on human subject were performed on the proposed device. The experimental results proved the ability of the proposed EEG recorder to acquire high-time-resolution ABRs while giving periodic auditory stimulation.